Journal of Pediatric Orthopaedics - 2026-04-09 - Journal Article
Preoperative MRI-Derived Navigation Reduces Radiation Exposure in Pediatric Spinal Fusion.
Cardin S, Reed LA, Atesok K, Herrera-Soto JA
Topics
Key Takeaway
MRI-to-synthetic CT navigation eliminated preoperative CT radiation (saving 19.6 mSv) while matching CT-based navigation intraoperative fluoroscopy time (~47–48 seconds) and effective dose (~0.55–0.57 mSv) in pediatric AIS fusion.
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Summary
This single-center retrospective study compared fluoroscopy-only, CT-based navigation, and MRI-to-synthetic CT navigation for pedicle screw placement in pediatric AIS posterior spinal fusion across 94 patients. Both navigation modalities reduced intraoperative fluoroscopy time by ~47% versus fluoroscopy-only (48–47 s vs. 90.9 s, P<0.001) and effective intraoperative dose (0.55–0.57 mSv vs. 0.91 mSv, P=0.008). MRI-to-CT navigation eliminated the 19.6 mSv preoperative CT dose while achieving intraoperative radiation profiles statistically equivalent to CT-based navigation.
Key Limitation
Pedicle screw accuracy (breach rate, revision rate) was not reported, so the clinical safety equivalence of MRI-to-synthetic CT navigation versus CT-based navigation remains unestablished.
Original Abstract
BACKGROUND
Minimizing radiation exposure during pediatric spinal deformity correction is critical due to the cumulative lifetime effects of ionizing radiation. This study uses preoperative MRI-derived synthetic CT data to potentially eliminate preoperative CT scans entirely and reduce the overall radiation load on patients undergoing spinal fusion for adolescent idiopathic scoliosis (AIS).
METHODS
A retrospective cohort study was performed on pediatric patients undergoing posterior spinal fusion for AIS with pedicle screw instrumentation at a single tertiary center. Three modalities were compared: fluoroscopy-only guidance, navigation with preoperative CT registration, and navigation with preoperative MRI converted to synthetic CT registration. Demographic, operative, and radiation parameters, including intraoperative fluoroscopy time and total pre- and intraoperative effective dose (mSv), were recorded and analyzed. MRI was converted to CT using machine learning models that translate the signal intensities of an MRI scan into the Hounsfield units (density values) typical of a CT scan.
RESULTS
A total of 94 patients were included in 3 groups: fluoro-only (n=39), CT-only (n=28), and MRI-to-CT conversion (n=27). Groups were demographically comparable (age, sex, BMI, preoperative major curve magnitude; all P>0.05). The number of fused levels and estimated blood loss were also comparable (P=0.827, 0.913, respectively). Intraoperative radiation exposure was significantly reduced in both navigation groups compared with the fluoroscopy-only group. Fluoroscopy time decreased from 90.9±28.0 seconds in the fluoroscopy-only cohort to 48.2±21.9 and 47.5±21.7 seconds in the CT-only and MRI-to-CT groups, respectively (P<0.001). Effective intraoperative dose was significantly higher in the fluoroscopy-only group (0.91±0.57 mSv) when compared with the CT-only group (0.57±0.49 mSv) and the MRI-to-CT group (0.55±0.49 mSv) (P=0.008). The fluoroscopy-only and MRI-to-CT groups were exposed to significantly less preoperative radiation when compared with the CT-only group (0 vs. 19.6 mSv; P<0.05), which does not include standard preoperative radiographs.
CONCLUSIONS
Both CT-based and MRI-to-CT navigation significantly reduced intraoperative radiation exposure compared with fluoroscopy-only guidance. MRI-to-synthetic CT navigation achieved intraoperative radiation profiles equivalent to those of CT-based registration while eliminating the need for a preoperative CT scan. These findings support MRI-to-CT navigation as a safe and efficient, radiation-sparing alternative for pedicle screw placement in pediatric deformity surgery.
LEVEL OF EVIDENCE
Level III, retrospective comparative study.