Spine - 2026-03-24 - Journal Article
Patient Specific Finite Element Modelling Outputs Outperform Clinical Metrics in Predicting Fusion Cage Subsidence.
Lali F, Raftery K, Levy H, Freedman B, Newell N
Topics
Key Takeaway
Patient-specific CT-derived finite element models predict TLIF cage subsidence with AUC=0.809 (average trabecular intermediate strain), outperforming cage length (AUC=0.797), cage width (AUC=0.750), and cage height (AUC=0.698).
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Summary
This study asked whether preoperative CT-derived patient-specific FE models outperform conventional clinical metrics in predicting severe cage subsidence (≥4 mm) after TLIF. FE models were built from CT scans of 42 patients (22 severe, 20 non-severe subsidence), with bone material properties assigned from Hounsfield units and cage position registered from postoperative imaging. Average trabecular intermediate strain achieved AUC=0.809, exceeding all clinical metrics, while peak endplate minimum principal stress reached AUC=0.775.
Key Limitation
The cohort of 42 patients is underpowered to establish generalizable AUC cutoffs, and the near-equal severe/non-severe split does not reflect the reported ~20% clinical incidence of severe subsidence, raising concerns about spectrum bias.
Original Abstract
STUDY DESIGN
Finite element (FE) analysis of retrospective clinical cohort.
OBJECTIVE
To determine whether preoperative CT-derived FE model outputs can improve subsidence prediction compared to conventional clinical measurements alone in patients undergoing transforaminal lumbar interbody fusion (TLIF).
SUMMARY OF BACKGROUND DATA
Cage subsidence occurs in approximately 20% of spinal fusion patients and can lead to complications requiring reoperation. While individual risk factors are known, no validated tool integrates patient anatomy, bone quality, and implant characteristics to predict subsidence. Finite element models have been hypothesized to predict subsidence but lack clinical validation.
METHODS
Patient-specific FE models were created from preoperative CT scans of 42 TLIF patients: N=22 Severe subsidence (≥4 mm); N=20 Non-severe subsidence (<4 mm). Vertebral geometries were segmented, and bone material properties were assigned based on Hounsfield units (HU). Cage positions from postoperative scans were registered to preoperative anatomy. Endplate and trabecular stresses and strains from FE models were compared to clinical measures using receiver operating characteristic analysis.
RESULTS
15 Principal stresses and strains of the FE simulations showed significantly higher values in severely subsided patients compared to the Non-Severe group. Average trabecular intermediate strain achieved the highest area under curve score (AUC=0.809), outperforming all clinical metrics. Peak endplate minimum principal stress (AUC=0.775) was the second-best FE classifier. Traditional clinical measures showed lower discriminative ability: cage length (AUC=0.797), cage width (AUC=0.750), and cage height (AUC=0.698).
CONCLUSION
Patient-specific FE model outputs significantly correlate with clinical subsidence outcomes and outperform several traditional metrics in classifying severe subsidence. Both endplate and trabecular stresses and strains are important predictors, with average values showing comparable or superior performance to peak values. Integration of FE models into the clinical workflow could provide a comprehensive preoperative subsidence prediction tool.