JAAOS - 2026-06-15 - Journal Article; Multicenter Study; Randomized Controlled Trial
Changes in Clinical Practice After Publication of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Randomized Controlled Trial.
Sabharwal S, Becker RG, Monument MJ, Schneider P, Schubert T, Ghert M, Morris CD
Topics
Key Takeaway
Following the PARITY RCT, the proportion of musculoskeletal oncologists limiting perioperative antibiotics to 24 hours doubled from 25% to 51% (P<0.001), yet 60% reported no meaningful practice change.
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Summary
This survey assessed practice change among musculoskeletal oncologists following the January 2022 PARITY RCT, which demonstrated no SSI difference between 1-day and 5-day postoperative IV antibiotic regimens but significantly higher antibiotic-related complications in the 5-day group. Of 101 respondents across six continents, 93% were aware of PARITY, but only 40% reported a meaningful practice change. The proportion prescribing 24-hour antibiotic courses doubled (25% to 51%, P<0.001), while oral antibiotic prescribing after discharge declined from 23% to 16% (P<0.001).
Key Limitation
Voluntary self-selection of survey respondents distributed through professional networks likely overrepresents academically engaged surgeons, inflating both PARITY awareness rates and reported practice change relative to the broader community.
Original Abstract
BACKGROUND
The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial was a multicenter randomized clinical trial comparing a 1-day with a 5-day postoperative intravenous antibiotic regimen after lower extremity bone tumor resection and endoprosthetic reconstruction. The trial found no difference in surgical site infections between groups, but a markedly increased risk for antibiotic-related complications in the 5-day group. The study was published in January 2022. The objective of this study was to assess the effect of these findings on the clinical practice of musculoskeletal oncologists.
METHODS
We developed an anonymous survey exploring changes in clinical practice after the publication of the PARITY trial and electronically distributed the survey to practicing musculoskeletal oncologists through REDCap in March 2024. Data were analyzed descriptively, and changes in practice from before to after the publication of the PARITY study were analyzed through the Pearson chi-square test.
RESULTS
We obtained 101 responses from surgeons across six continents. Nearly all respondents (94 of 101, 93%) were aware of the PARITY trial results. Forty respondents (40%) reported a meaningful change in clinical practice after PARITY, most frequently a reduction of antibiotic administration in >75% of patients. After PARITY, the proportion of respondents who reported limiting antibiotics to 24 hours increased from 25% to 51% ( P < 0.001), and the proportion prescribing oral antibiotics after discharge from the hospital declined from 23% to 16% ( P < 0.001). Among those who did not change their practice, personal experience/professional opinion was the most frequently cited reason. Adherence to institutional standards was cited as an additional barrier.
CONCLUSIONS
Many respondents reported meaningful change in their clinical practice after the publication of the PARITY trial, most notably limiting perioperative antibiotics to 24 hours. The complexities influencing the personal decision to adopt a notable change in clinical practice in response to new evidence warrant additional study.
LEVEL OF EVIDENCE
IV.