Pediatric Orthopaedics
prospective cohort
LOE II
n = 74
Mean 63.4 months (5–8 years)
Imbeault R, Shen J · … · Parent S
Key Takeaway: At mean 63-month follow-up, VBT achieved a final instrumented Cobb angle of 25.7° from a preoperative mean of 47.9°, but 66% had radiographic tether breakage and 21.6% required unplanned return to the OR.
Arthroplasty
RCT
LOE I
n = 60
48 hours postoperative
Pietraszek P, Reysner T · … · Reysner M
Key Takeaway: Combined iPACK + ACB reduced 48-hour opioid consumption by 3.2 mg MME versus two-level lumbar-sacral ESPB (9.7 vs 12.9 mg MME; p=0.035) in elderly TKA patients.
Arthroplasty
prospective cohort
LOE II
n = 664
24 months with intervals at 3, 6, 12, and 24 months
Nin DZ, Chen YW · … · Smith EL
Key Takeaway: 72.4% of TKA patients achieved MCID on KOOS JR by 12 months, but 9.9% were delayed achievers (by 24 months) and 11.0% failed to maintain early MCID gains.
Trauma
prospective cohort
LOE II
n = 102 (plus 10 healthy controls)
Minimum 8 months; MRI at 3 and 8 months postoperatively.
Teixeira TM, Martins EC
Key Takeaway: Serial MRI at 3 and 8 months post-IFN showed peroneal tendon thickness equivalent to healthy controls (brevis 2.9 vs 2.8 mm, longus 3.4 vs 3.4 mm; TOST p<0.001) with zero MRI-detectable pathology across 102 patients.
Arthroplasty
prospective cohort
LOE II
n = 143
3 months
Schiegl J, Bammert P · … · Kappenschneider T
Key Takeaway: In geriatric patients undergoing THA or TKA, median Geriatric Depression Scale scores declined from 8.5 to 4 at 3 months in those with elevated baseline symptoms (GDS 6–15), with most improvement occurring in the early postoperative period.
Musculoskeletal Oncology
meta-analysis
LOE II
n = 11,272 patients (number of studies not specified in abstract)
N/A
Gao M, Qiu Z · … · Gao T
Key Takeaway: Pooled pelvic insufficiency fracture incidence after pelvic radiotherapy is 17% (95% CI: 15–20%) across 11,272 female patients, with sacral/SI joint involvement in 71% of cases and definitive RT carrying a 25% fracture rate versus 6% with adjuvant RT.
Musculoskeletal Oncology
retrospective cohort
LOE III
n = 117 (26 early, 91 late)
Not explicitly reported as mean; 5-year Kaplan-Meier endpoints used.
Jahn J, Dean KK · … · Pretell-Mazzini J
Key Takeaway: Late sarcoma specialist consultation (>2 months) after unplanned excision independently increased the odds of 5-year metastasis 7.1-fold (OR=7.11) and mortality 11.3-fold (OR=11.29) compared to consultation within 2 months.
Foot & Ankle
retrospective cohort
LOE III
n = 116 enrolled; n=72 after propensity score matching (36 per group)
Mean 34.6 months (LTT group), 39.8 months (SCR-only group); minimum 2 years.
Zhou X, Ying L · … · Chen S
Key Takeaway: Adding lower trapezius transfer to LHBT-based superior capsular reconstruction improves postoperative external rotation by 14.7° (35.3° vs 20.6°, p<0.001) and reduces infraspinatus retear rate from 27.8% to 5.6% (OR=0.11) in massive posterosuperior irreparable rotator cuff tears with Goutallier ≥3 fatty infiltration.
Arthroplasty
retrospective cohort
LOE III
n = 627 (propensity-matched from 822 total; 209 DM-THA vs 418 c-THA)
Up to 5 years.
Koh CK, Lee J · … · Grammatopoulos G
Key Takeaway: Dual mobility THA reduced 5-year dislocation incidence from 4.8% to 0.5% compared to conventional THA in femoral neck fracture patients without increasing overall revision rates.
Pediatric Orthopaedics
database study
LOE III
n = 2371 patients from 13 hospitals
N/A
Halpern LM, Zhang DA · … · Bronson W
Key Takeaway: Spinal opioid and epidural analgesia reduce total opioid consumption by more than 50% compared to PCA (1.7 and 1.9 vs. 4.1 OME/kg) after posterior spinal fusion for AIS, without improving pain scores, complication rates, or length of stay.
Arthroplasty
retrospective cohort
LOE III
n = 932
Mean not specified; outcomes collected at 6 weeks, 3 months, and 1 year postoperatively.
Reddy H, Di Gangi C · … · Meftah M
Key Takeaway: All three patella-related complications (including two reoperations) in 932 RA-TKA cases occurred exclusively in the valgus-internal rotation femoral component cohort (Val-IR, 15% of cases), despite no significant difference in KOOS JR or PROMIS scores at one year across alignment groups.
Shoulder & Elbow
database study
LOE III
n = 704,930 (83,203 TSA; 267,683 THA; 354,044 TKA)
N/A
Joshi T, Kalva S · … · Virk MS
Key Takeaway: TSA incidence grew 248% from 2015–2025 (13.1 to 45.6 per 100,000) and is projected to increase by 73–397% by 2040, representing the highest proportional annual growth rate (12.4%/year by Poisson modeling) of any major arthroplasty.
Arthroplasty
database study
LOE III
n = 420,053 primary THA; 1,942 early dislocators vs 360,493 controls
2-year cumulative incidence from 90-day landmark point
Fuqua AA, Hrudka BT · … · Wilson JM
Key Takeaway: Early dislocation within 90 days of primary THA carries a 29.0% rate of recurrent dislocation or aseptic revision by 2 years versus 1.3% in controls, with HR 22.6 for all-cause revision.
Arthroplasty
retrospective cohort
LOE III
n = 66 hips (33 ITD, 33 IFL)
Mean 27.9 months (ITD) vs 56.3 months (IFL).
Schab AR, Kuhns BD · … · Domb BG
Key Takeaway: Iliopsoas tunnel deepening achieved 78.8% resolution of painful internal snapping at minimum 2-year follow-up, equivalent to the 81.8% resolution seen with fractional lengthening (P=.76).
Pediatric Orthopaedics
retrospective cohort
LOE III
n = 150 children (187 hips)
Mean 7.6 years (range 5–14 years)
Liao W, Ma Y · … · Lyu X
Key Takeaway: Ischiopubic synchondrosis fusion before age 5 years is associated with an 82.9% rate of residual acetabular dysplasia after closed reduction for DDH, versus 63.2% in those fusing at age 5 or older.
Arthroplasty
retrospective cohort
LOE III
n = 50 hips (34 normal anteversion, 16 excessive anteversion)
Minimum 2 years.
Matsushita Y, Murata Y · … · Uchida S
Key Takeaway: Excessive femoral anteversion (>25°) is associated with significantly worse 2-year PROMs after hip arthroscopy for FAIS, including iHOT12 scores of 79.1 vs 95.1, and a 75% vs 29.4% prevalence of anteroinferior labral tears.
Arthroplasty
database study
LOE III
n = 686,229
2016–2023 (7-year observation period)
Kistler NM, Iyer A · … · Heckmann ND
Key Takeaway: High-risk TJA patients (Elixhauser Index ≥95th percentile) are concentrated at teaching hospitals at a significantly higher rate than non-teaching hospitals (7.39% vs. 6.16%, p<0.001), with teaching hospital comorbidity burden increasing while non-teaching hospitals decreased by 0.2 EI points from 2016–2023.
Pediatric Orthopaedics
retrospective cohort
LOE III
n = 66 patients, 101 feet
Mean 3.7 years (±3.5 years)
Westberry DE, Bailey CE · … · Thurston RC
Key Takeaway: Surgical reconstruction of cleft foot in 101 feet reduced forefoot splay angle from 36.14° to 21.39° (P<0.001) with an 8% revision rate over mean 3.7-year follow-up.
Arthroplasty
retrospective cohort
LOE III
n = 306 (43 septic, 263 non-septic; 121 hip, 185 knee)
2005–2022 chart review; follow-up duration not explicitly reported as mean value.
Tran DH, Yang KJ · … · Brown N
Key Takeaway: PJI patients presenting with concomitant sepsis had 81.4% all-cause mortality during follow-up versus 50.6% in non-septic PJI patients, with hip sepsis patients reaching only 42% one-year survival.
Shoulder & Elbow
retrospective cohort
LOE III
n = 84 (41 stress CT, 43 static CT)
N/A
Badre A, Abdullah H Awad M · … · Goetz T
Key Takeaway: Gravity varus stress CT reduced the false-negative rate for detecting instability in isolated coronoid fractures from 82% (static CT) to 11% (p<0.001).
Arthroplasty
retrospective cohort
LOE III
n = 1,164
Mean 32 months (range 28–41 months).
Liu D, Wang X · … · Liu G
Key Takeaway: Osteoporotic UKA patients had significantly lower KSS functional scores and FJS than normal-BMD patients at mean 32-month follow-up, and within the osteoporotic cohort, mobile-bearing prostheses outperformed fixed-bearing on KSS functional score (P=0.007) and FJS (P=0.026).
Arthroplasty
retrospective cohort
LOE III
n = 5,109 hips
1 year postoperative
van Duren BH, Pursun Y · … · Malviya A
Key Takeaway: Patients with the highest preoperative anxiety/depression scores achieved MCID on iHOT-12 at significantly lower rates than those without (47% vs 63%, P=.031) after hip arthroscopy for FAI syndrome.
Arthroplasty
database study
LOE III
n = 593,013 (PsC n=10,230; PsA n=1,445; control n=581,338)
90-day infectious outcomes; 2-year revision rates
Durbin JW, Cui E · … · Villa JC
Key Takeaway: PsA patients undergoing THA carry a 4.7-fold increased odds of 90-day sepsis and 2.9-fold increased odds of deep SSI compared to controls, while PsC patients show a 2.3-fold increased superficial SSI risk and 2.8-fold sepsis risk.
Trauma
retrospective cohort
LOE III
n = 4,052 (2,026 per matched group)
Up to 15 years; primary outcome at 2 years.
Elnaggar A, Almaat A · … · Vaidya R
Key Takeaway: In propensity-matched elderly patients with acetabular fractures, ORIF carries a 69% higher relative risk of revision arthroplasty at 2 years compared to acute THA (10.4% vs 6.1%), but acute THA has significantly higher early infection (7.1% vs 4.5%) and dislocation (5.7% vs 4.3%) rates.
Arthroplasty
meta-analysis
LOE III
n = 22 studies, 161,326 patients
Mean 2.6 years
Al-Saidi N, Al-Saidi N · … · Bydon M
Key Takeaway: In 161,326 patients with concomitant lumbar fusion and THA, operative order (SAHA vs. HASA) produced no significant difference in hip dislocation, mechanical loosening, periprosthetic fracture, DVT, infection, or revision rates (3.6% vs. 2.6%, P=0.5).
Foot & Ankle
case-control
LOE III
n = 73 participants, 120 WBCT scans (40 CMT, 40 idiopathic cavovarus, 40 controls)
N/A — cross-sectional morphologic study
Behrens A, Schonhorst N · … · Chrea B
Key Takeaway: CMT cavovarus demonstrates forefoot adduction 3× greater than controls and a significantly lower transverse arch plantar angle (94.2°) versus idiopathic cavus (100.5°) and controls (102.7°), confirming quantifiable multiplanar morphologic distinctions on WBCT.
Spine
biomechanical
LOE III
n = 42
N/A
Lali FHV, Raftery KA · … · Newell N
Key Takeaway: Patient-specific CT-derived finite element models predict TLIF cage subsidence with AUC=0.809 (average trabecular intermediate strain), outperforming cage length (AUC=0.797), cage width (AUC=0.750), and cage height (AUC=0.698).
Foot & Ankle
retrospective cohort
LOE III
n = 44 (22 matched pairs)
Mean 84.6 ± 45.9 months
Yang S, Liu Z · … · Guo Q
Key Takeaway: AOPT for large cystic OLTs yields equivalent FAOS improvement (~35 points) and MOCART 2.0 scores (~73) regardless of lesion laterality at mean 84.6 months follow-up.
Spine
retrospective cohort
LOE III
n = 16,684 (8,342 matched pairs)
5-year revision-free survival; 90-day complication and reimbursement data
Green CK · … · Lockey SD
Key Takeaway: Outpatient single-level ALIF/LLIF demonstrated higher 5-year revision-free survival (log-rank P=0.007) and 40% lower median 90-day global reimbursements ($5,169 vs. $6,779) compared to matched inpatient controls.
Foot & Ankle
retrospective cohort
LOE III
n = 65 ankles in 60 patients
November 2019 to June 2024 (up to ~4.5 years); mean not explicitly reported.
Nakasa T, Ikuta Y · … · Adachi N
Key Takeaway: CFL injury on preoperative MRI independently predicts recurrent instability after arthroscopic ATFL repair with an OR of 9.00 (95% CI 1.95–56.22), with thin-type CFL morphology carrying a 31.5% recurrence rate.
Pediatric Orthopaedics
retrospective cohort
LOE III
n = 140 fractures in 138 patients
Median 6.8 years (range 5–10 years)
Zilliacus K, Nietosvaara Y · … · Grahn P
Key Takeaway: Primary displacement ≥3 mm carries a 6.7-fold increased odds of complications in pediatric proximal radius fractures, with surgical treatment itself associated with 5.0-fold greater odds of unfavorable functional outcome.
Hand & Wrist
retrospective cohort
LOE III
n = 667
Not explicitly reported; follow-up inferred from outpatient visit counts during fracture management episode.
Kaya S · … · Dursun MA
Key Takeaway: Soft bandage management of pediatric distal radius torus fractures reduced total societal cost by 33–47% compared to short and long arm splints ($23.46 vs $34.82 vs $44.06), with a projected $7,773 combined saving over the study period.
Foot & Ankle
case-control
LOE III
n = N not explicitly stated in abstract; four groups: ankle fracture, PTOA (post-fracture end-stage), NTOA, and control
N/A
Matthias J, David MA · … · Hunt KJ
Key Takeaway: WNT7B is the most strongly upregulated gene in fracture and PTOA synovium, with WNT pathway activation significantly broader in PTOA than in nontraumatic OA, supporting a molecularly distinct PTOA subtype.
Arthroplasty
retrospective cohort
LOE III
n = 151
Minimum 2 years.
Nishiura R, Nakazawa K · … · Terai H
Key Takeaway: Stem subsidence (≥5 mm) occurred in 13.2% of RSA press-fit short stems, with metaphyseal filling ratio <70% (OR 0.90) and osteoporosis (OR 3.2) as independent predictors.
Arthroplasty
database study
LOE III
n = n>45,100 (>24,000 THA, >20,000 TKA, >1,100 RTSA)
6 months postoperative
Gill SD, Page RS · … · Ackerman IN
Key Takeaway: Despite statistically significant reductions in preoperative EQ-5D-5L scores during COVID-19, the adjusted mean difference was ≤0.03 points—not clinically meaningful—while THA and TKA patient satisfaction paradoxically increased by approximately 5 percentage points during the pandemic.
Arthroplasty
retrospective cohort
LOE III
n = 59 hips (58 patients)
N/A (preoperative imaging study)
Spilo K, Miller TT · … · Boettner F
Key Takeaway: EOS and lateral pelvic radiographs agreed on only 9 of 24 total high-risk patients identified (37.5% overlap), with a mean sit-to-stand sacral slope discrepancy of 7.2° between modalities.
Pediatric Orthopaedics
retrospective cohort
LOE III
n = 668,595 fractures
20-year study period (1999–2018); no individual patient follow-up reported.
Lund AR · … · Viberg B
Key Takeaway: The overall incidence rate of pediatric extremity fractures in Denmark was 3,164 per 100,000 persons/year over 20 years, with forearm fractures most common and upper/lower leg fractures the only anatomical sites showing a declining trend.
Arthroplasty
retrospective cohort
LOE III
n = 56 feet (55 patients)
Mean 361 ± 69 days (~12 months)
Werneburg F, Arbab D · … · Gutteck N
Key Takeaway: MIS and open talonavicular arthrodesis produced equivalent AOFAS gains (36.2 vs. 30.9 points) at mean 361-day follow-up with no significant difference in operative time (59.2 vs. 69.6 min).
Sports Medicine
retrospective cohort
LOE IV
n = 36 knees (24 unipolar, 12 bipolar) from 35 patients
Mean 3.58 years (unipolar 3.87 vs bipolar 3.00 years)
Acheampong KK, Augustin EJ · … · Yanke AB
Key Takeaway: Bipolar patellofemoral OCA transplantation had a 25% structural graft failure rate versus 0% for unipolar, but cumulative lesion area—not bipolarity per se—was the independent predictor of failure (OR 1.005 per mm²).
Arthroplasty
retrospective cohort
LOE IV
n = 51
Median 14 years (range 10–18 years).
Rhyu KH · … · Lee MG
Key Takeaway: Cementing a polyethylene liner into Harris-Galante II shells yielded 77% survivorship free from acetabular cup revision at 15 years with a 39% overall complication rate.
Hand & Wrist
systematic review
LOE IV
n = 8 studies, 662 ACLRs
Range 5–23 years across included studies.
Hopper HM, Harris M · … · Amendola A
Key Takeaway: Quadriceps tendon autograft ACLR demonstrates graft failure rates of 0–24% and anterior knee pain rates of 0–5% at 5–23 year follow-up across 662 reconstructions.
Trauma
systematic review
LOE V
n = N/A
N/A
Stewart H, Watkins A · … · Sponseller PD
Key Takeaway: MRI-based synthetic CT techniques (ZTE, UTE, 3D-GRE, and deep learning-based sCT) demonstrate high agreement with conventional CT across multiple anatomical sites, with deep learning models showing the strongest improvement trajectory despite limited training datasets.
Arthroplasty
retrospective cohort
LOE IV
n = 39
Mean 11.7 years (range 120–165 months).
Simske NM, Sandler AB · … · Parnes N
Key Takeaway: Arthroscopic posterior labral repair in active-duty military patients yields 92.3% return to full military duty and 87.2% return to sport at mean 11.7 years, with ASES improving from 46.7 to 87.8.
Pediatric Orthopaedics
retrospective cohort
LOE IV
n = 34 (from 3,053 total SCH fractures)
Not reported as a mean duration; pin removal at mean 4.7 ± 1 weeks.
Emet A, Armet G · … · Dede O
Key Takeaway: Open supracondylar humerus fractures represent 1.1% of all pediatric SCH fractures and carry a 20.6% nerve injury rate and 26.5% reoperation rate.
Foot & Ankle
retrospective cohort
LOE IV
n = 955 primary TAA patients; 12 PJI cases analyzed
Median 5.7 years
Teehan E, Braswell MJ · … · Demetracopoulos CA
Key Takeaway: PJI after TAA occurred at 1.3% (12/955 patients, 5.4 per 1000 person-years), with only 50% overall implant retention and 2 of 5 chronic PJI patients ultimately requiring below-knee amputation.
Sports Medicine
cadaveric
LOE V
n = 8 cadaveric shoulders
N/A
Iio R · … · Athwal GS
Key Takeaway: Anterior harvest deltoid osteomuscular transfer (DOT) from the distal clavicle significantly suppressed humeral head superior translation versus massive irreparable rotator cuff tear (MRCT) alone at 0° and 30° of glenohumeral elevation across all applied force conditions (0–30 N).
Shoulder & Elbow
cost-effectiveness
LOE V
n = N/A
N/A
Menendez ME · … · Matsen FA
Key Takeaway: Robotic-assisted rTSA requires an absolute risk reduction in early revision of 6.55% (1 revision prevented per 15 cases) to break even, which exceeds the observed baseline early revision rate of 2.1%, making routine economic justification impossible under current conditions.
Sports Medicine
cadaveric
LOE V
n = 8 cadaveric knees
N/A
Uppstrom TJ, Hollenbeck JFM · … · Provencher CRMT
Key Takeaway: Both tibia-based suture anchor and capsular-based side-to-side repair of type 3 lateral meniscal oblique radial tears restored lateral compartment contact mechanics, meniscal extrusion, and anterior root forces to intact-state values, while debridement failed to do so across all four flexion angles tested.
Trauma
biomechanical
LOE V
n = 12 (3 per group)
8 weeks
Glatt V · … · Woloszyk A
Key Takeaway: A biomimetic hematoma scaffold delivering 42 µg rhBMP-2 achieved superior predicted torsional strength (highest pMOI, p<0.0001) in a 2.5 cm goat tibial defect compared to ACS delivering 50-fold higher dose (2.1 mg rhBMP-2).
Basic Science
prospective cohort
LOE V
n = 48 rats (n=6 per timepoint, 8 timepoints)
35 days post-ACLT
Zhao ZD, Yu KK · … · Li CB
Key Takeaway: In a rat ACLT model, detectable macroscopic joint changes and peak M1 macrophage infiltration occur by day 7, with osteoclast activity elevated from day 3, establishing a PTOA intervention window within 1 week of injury.
Arthroplasty
retrospective cohort
LOE IV
n = 108 (110 enrolled)
Mean 47.6 months (range 12–96.7 months)
Leggieri F, Braconi L · … · Baldini A
Key Takeaway: Lateral UKA via medial parapatellar approach achieved 97.2% 7-year survivorship with 99.0% of patients meeting KSS-Knee PASS thresholds at mean 47.6 months in 108 patients.
Arthroplasty
retrospective cohort
LOE IV
n = 157
Not reported.
Kwon M · … · Sung KS
Key Takeaway: Modified Broström using absorbable sutures alone achieved mean AOFAS improvement of 21.4 points (66.84→88.20) with 6.3% recurrence and 1.2% reoperation rate at mean follow-up not specified.
Arthroplasty
retrospective cohort
LOE IV
n = 875 (BC n=122, IT n=523, VFN n=230)
October 2014 to March 2025; short- and long-term outcomes reported, specific mean follow-up duration not stated.
Hammond B, Fong C · … · Egol K
Key Takeaway: Basicervical hip fractures (AO/OTA 31B3) show comparable long-term outcomes to intertrochanteric and valgus femoral neck fractures but carry significantly higher rates of minor in-hospital complications even after multivariate adjustment, with no significant difference in outcomes across fixation constructs within the basicervical cohort.
Arthroplasty
retrospective cohort
LOE IV
n = 201
3 weeks postoperative
Gay A, Noailles T · … · Hardy A
Key Takeaway: Preoperative anxiety (APAIS >11) in ACL reconstruction patients was associated with a 2.5-fold increase in level 2 analgesic use and a 7-fold increase in locoregional anesthesia requirement in the recovery room, but did not predict flexion contracture at 3 weeks.
Trauma
biomechanical
LOE V
n = N/A
3 weeks post-fracture
Muire PJ, Baldridge M · … · Levack AE
Key Takeaway: A rat femur fracture model inoculated with biofilm-derived S. aureus (10⁴–10⁵ CFU/mL) and stabilized with stainless-steel hardware produced >10⁶ CFU/mL on both bone and implant at 3 weeks despite surgical debridement and cefazolin, with no significant difference in bacterial burden between compartments.
Spine
Not available
LOE NOT REPORTED
n = Not reported
Not reported
Kumar R, Bansal A · … · Louie P
Key Takeaway: Abstract not available — see the original article for details.
Trauma
biomechanical
LOE V
n = 12 synthetic proximal femora
N/A
Llano L, Ziegler P · … · Stoffel K
Key Takeaway: Protective plating with screw overlap (short or long) beyond the innermost nail interlocking screws significantly reduces interimplant femoral strains versus no-overlap or no-plate configurations under 200 N axial load in osteoporotic synthetic bone.
Arthroplasty
cadaveric
LOE V
n = 7 fresh-frozen cadaveric legs
N/A
Demeulenaere M, Taylan O · … · Scheys L
Key Takeaway: The Next-AR intraoperative navigation platform achieved implant alignment within a mean bias ≤1.5° of target across all six alignment parameters in cadaveric medially-stabilized TKA, with RMSE ≤2.3°.
Hand & Wrist
systematic review
LOE V
n = N/A
N/A
Lam W · … · Rhee P
Key Takeaway: Hyperselective neurectomy and tendon lengthening each address upper limb spasticity tone management through distinct mechanisms, but no high-level evidence currently establishes superiority of one over the other in functional or non-functional hands.